Format

Send to

Choose Destination
Biol Blood Marrow Transplant. 2019 Jan;25(1):151-156. doi: 10.1016/j.bbmt.2018.08.005. Epub 2018 Aug 10.

Vascular Structure and Function in Cancer Survivors after Hematopoietic Stem Cell Transplantation.

Author information

1
School of Kinesiology, University of Minnesota, Minneapolis, Minnesota; Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota. Electronic address: denge001@umn.edu.
2
Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota.
3
Biostatistical Design and Analysis Center, Clinical and Translational Sciences Institute, University of Minnesota, Minneapolis, Minnesota.
4
Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, Minnesota.
5
Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.

Abstract

This study examined the effects of hematopoietic cell transplantation (HCT) and associated preparative regimens on vascular structure and function. Measures of carotid artery stiffness and brachial artery endothelial-dependent dilation were obtained in patients who had survived ≥ 2 years after HCT for hematologic malignancy and were diagnosed at ≤21 years. HCT survivors (n = 108) were examined: 66 received total body irradiation (TBI) alone or with a low-dose cranial radiation boost (TBI±LD-CRT), 19 received TBI plus high-dose cranial radiation (TBI+HD-CRT), and 23 received a chemotherapy-only preparative regimen (CHEMO). Siblings (n = 83) were invited to participate as control subjects. Although endothelial-dependent dilation did not differ between siblings and HCT survivors, carotid cross-sectional compliance, cross-sectional distensibility, diameter compliance, and diameter distensibility were greater in siblings than HCT survivors. Comparing the HCT preparative regimens, carotid cross-sectional compliance, cross-sectional distensibility, diameter compliance, diameter distensibility, and incremental elastic modulus were significantly lower in the TBI+HD-CRT group compared with siblings or with TBI±LD-CRT and CHEMO treatment groups. Cross-sectional distensibility and diameter compliance were significantly lower in the TBI±LD-CRT group compared with siblings. TBI±LD-CRT and CHEMO groups did not differ from each other in these vascular measures. HCT preparative regimens containing TBI+HD-CRT resulted in greater arterial decrements, indicating increased risk for cardiovascular disease.

KEYWORDS:

Cancer survivors; Compliance; Distensibility; Endothelial function; Ultrasound

PMID:
30103017
PMCID:
PMC6310642
[Available on 2020-01-01]
DOI:
10.1016/j.bbmt.2018.08.005

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center