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Med Sci Sports Exerc. 2019 Jan;51(1):56-64. doi: 10.1249/MSS.0000000000001754.

Leucine Metabolites Do Not Enhance Training-induced Performance or Muscle Thickness.

Author information

1
Laboratory of Physiology and Biochemistry of Exercise, Faculty of Human Kinetics, Universidade de Lisboa, Cruz Quebrada, PORTUGAL.
2
Laboratory of Exercise and Health, Faculty of Human Kinetics, Universidade de Lisboa, Cruz Quebrada, PORTUGAL.
3
Center for the Study of Human Performance, Faculty of Human Kinetics, Universidade de Lisboa, Cruz Quebrada, PORTUGAL.
4
Neuromuscular Research Lab, Faculty of Human Kinetics, Universidade de Lisboa, Cruz Quebrada, PORTUGAL.
5
Faculty of Health and Sports, Universidade Europeia, Laureate International Universities, Lisboa, PORTUGAL.
6
Faculty of Health, Sport and Human Performance, The University of Waikato, Hamilton, NEW ZEALAND.
7
Department of Kinesiology, McMaster University, Hamilton, ON, CANADA.

Abstract

Leucine metabolites, α-hydroxyisocaproic acid (α-HICA) and β-hydroxy-β-methylbutyrate (calcium, HMB-Ca and free acid, HMB-FA), have been proposed to augment resistance training-induced changes in body composition and performance.

PURPOSE:

We aimed to conduct a double-blind randomized controlled pragmatic trial to evaluate the effects of off-the-shelf leucine metabolite supplements of α-HICA, HMB-FA, and HMB-Ca on resistance training-induced changes in muscle thickness and performance.

METHODS:

Forty men were randomly assigned to receive α-HICA (n = 10, fat-free mass [FFM] = 62.0 ± 7.1 kg), HMB-FA (n = 11, FFM = 62.7 ± 10.5 kg), HMB-Ca (n = 9, FFM = 65.6 ± 10.1 kg), or placebo (PLA; n = 10, FFM = 64.2 ± 5.7 kg). The training program consisted of whole body thrice weekly resistance training for 8 wk (seven exercises per session, three to four sets per session, at 70%-80% one repetition maximum). Skeletal muscle thickness by ultrasound, performance measures, and blood measures (creatine kinase, insulin-like growth factor 1, growth hormone, cortisol, and total testosterone) were evaluated at baseline and at the end of weeks 4 and 8.

RESULTS:

Time-dependent changes were observed for muscle thickness (P < 0.001), one repetition maximum bench press and squat (P < 0.001), Wingate peak power (P = 0.02), countermovement jump height (P = 0.03), power (P = 0.006), creatine kinase, insulin-like growth factor-1, growth hormone, and cortisol (all P < 0.001). No significant between-group or time-group interactions were observed.

CONCLUSIONS:

No leucine metabolite resulted in any ergogenic effects on any outcome variable. Supplementation with leucine metabolites-α-HICA, HMB-FA, or HMB-Ca-is not a supplementation strategy that improves muscle growth and strength development in young adult men.

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