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Curr Alzheimer Res. 2018;15(12):1106-1113. doi: 10.2174/1389200219666180813144834.

Probiotic Supplementation in Patients with Alzheimer's Dementia - An Explorative Intervention Study.

Author information

1
Department of Gerontology, Neuromed Campus, Kepler University Clinic, Linz, Austria.
2
Biovis Diagnostik MVZ GmbH, Limburg, Germany.
3
Division of Biological Chemistry, Biocenter, Medical University of Innsbruck, Innsbruck, Austria.
4
Division of Medical Biochemistry, Biocenter, Medical University of Innsbruck, Innsbruck, Austria.

Abstract

BACKGROUND:

Dysbiosis of intestinal microbiota in the elderly can cause a leaky gut, which may result in silent systemic inflammation and promote neuroinflammation - a relevant pathomechanism in the early course of Alzheimer's disease.

OBJECTIVE:

The rebalancing of the microbiome could benefically impact on gut inflammation and immune activation.

METHODS:

In this study, routine laboratory tests in twenty outpatients (9 females, 11 males, aged 76.7 ± 9.6 years) with Alzheimer's disease were investigated. The mean Mini Mental State Examination score was 18.5 ± 7.7. Biomarkers of immune activation - serum neopterin and tryptophan breakdown - as well as gut inflammation markers and microbiota composition in fecal specimens were analyzed in 18 patients before and after probiotic supplementation for 4 weeks.

RESULTS:

After treatment a decline of fecal zonulin concentrations and an increase in Faecalibacterium prausnitzii compared to baseline were observed. At the same time, serum kynurenine concentrations increased (p <0.05). Delta values (before - after) of neopterin and the kynurenine to tryptophan ratios (Kyn/Trp) correlated significantly (p <0.05).

CONCLUSION:

Results show that the supplementation of Alzheimer's disease patients with a multispecies probiotic influences gut bacteria composition as well as tryptophan metabolism in serum. The correlation between Kyn/Trp and neopterin concentrations points to the activation of macrophages and/or dendritic cells. Further studies are warranted to dissect the potential consequences of Probiotic supplementation in the course of Alzheimer's disease.

KEYWORDS:

Alzheimer`s disease; Faecalibacterium prausnitzii; Gut microbiota; brain-gut axis; dementia; neopterin; neuroinflammation; probiotics.

PMID:
30101706
PMCID:
PMC6340155
DOI:
10.2174/1389200219666180813144834
[Indexed for MEDLINE]
Free PMC Article

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