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Vasc Med. 2018 Oct;23(5):467-475. doi: 10.1177/1358863X18789783. Epub 2018 Aug 13.

Association of HIV infection with age and symptomatic carotid atherosclerotic disease at the time of carotid intervention in the United States.

Author information

1
1 UC San Diego School of Medicine, La Jolla, CA, USA.
2
2 Department of Surgery, Division of Vascular and Endovascular Surgery, UC San Diego, San Diego, CA, USA.
3
3 Department of Medicine, Division of Infectious Diseases and Global Public Health, UC San Diego, San Diego, CA, USA.
4
4 Section of Infectious Diseases and Tropical Medicine and Division of Pulmonology, Medical University of Graz, Graz, Austria.
5
5 Department of Anesthesiology, Division of Regional Anesthesia, UC San Diego, San Diego, CA, USA.
6
6 Department of Medicine, Division of Biomedical Informatics, UC San Diego, San Diego, CA, USA.

Abstract

The primary objectives of this work were: (1) to describe trends in HIV prevalence among those undergoing carotid intervention (carotid endarterectomy or carotid artery stenting) in the United States; and (2) to determine if HIV infection is independently associated with symptomatic carotid atherosclerotic disease or age at the time of carotid intervention. In a nationally representative inpatient database from 2004 to 2014, HIV infection was associated with younger age at the time of carotid intervention (59 years [SE 0.2] vs 71 years [SE 0.01], p < 0.001), male sex (83% vs 58%, p < 0.001), black race (21% vs 4%, p < 0.001), and symptomatic carotid atherosclerotic disease (18.8% vs 11.0%, p < 0.001). Among those undergoing carotid intervention, there was a significant increase in the prevalence of HIV from 0.08% in 2004 to 0.17% in 2014 ( p < 0.001). After adjustment for patient demographics, comorbidities and other covariates, HIV infection remained significantly associated with younger age (-8.9 years; 95% CI: -9.7 to -8.1; p < 0.001) at the time of carotid intervention, but HIV infection was not independently associated with symptomatic carotid atherosclerotic disease.

KEYWORDS:

HIV; atherosclerosis; carotid artery disease; endarterectomy; epidemiology; population health; stent

PMID:
30101684
PMCID:
PMC6380352
DOI:
10.1177/1358863X18789783
[Indexed for MEDLINE]
Free PMC Article

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