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Curr Nutr Rep. 2018 Sep;7(3):70-84. doi: 10.1007/s13668-018-0237-y.

Folate and Its Impact on Cancer Risk.

Author information

1
Department of Nutrition, Cancer Treatment Centers of America, 1331 East Wyoming Ave, Philadelphia, PA, 19124, USA.
2
, RD, LLC 10645 N. Tatum Blvd., Suite 200, Mailbox 122, Phoenix, Arizona, 85028, USA.
3
Department of Nutrition, Cancer Treatment Centers of America, 14200 W. Celebrate Life Way, Goodyear, Arizona, 85338, USA.
4
Department of Medicine and Science, Cancer Treatment Centers of America, 2610 Sheridan Road, Zion, IL, 60099, USA. Carolyn.Lammersfeld@ctca-hope.com.

Abstract

PURPOSE OF REVIEW:

Research has evaluated the potential impact of folate on cancer risk with conflicting findings. Studies have demonstrated increased risk, no effect, and decreased risk. This review summarizes findings of mixed results between folate intake, serum levels, gene polymorphisms, and cancer risk based on meta-analyses from the past five years.

RECENT FINDING:

Low or deficient folate status is associated with increased risk of many cancers. Folic acid supplementation and higher serum levels are associated with increased risk of prostate cancer. Gene polymorphisms may impact risk in certain ethnic groups. Folate has been studied extensively due to its role in methylation and nucleotide synthesis. Further prospective studies are needed to clarify optimal levels for nutrient remediation and risk reduction in those at risk, as well as elucidate the association between high intake, high serum levels, and prostate cancer risk. Future considerations for cancer risk may include gene interactions with nutrients and environmental factors.

KEYWORDS:

Cancer risk; Folate; Folate deficiency; Folate supplementation; Folic acid; MTHFR; SHMT; Serum folate

PMID:
30099693
PMCID:
PMC6132377
DOI:
10.1007/s13668-018-0237-y
[Indexed for MEDLINE]
Free PMC Article

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