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J Reprod Immunol. 2018 Nov;130:7-10. doi: 10.1016/j.jri.2018.07.006. Epub 2018 Jul 25.

Local and systemic levels of cytokines and danger signals in endometriosis-affected women.

Author information

1
Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria.
2
Department of Paediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria.
3
Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
4
Department of Paediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria. Electronic address: thomas.eiwegger@sickkids.ca.

Abstract

Endometriosis is a prevalent gynaecological disorder with a still unclear pathogenesis. So far inflammatory mechanisms are associated with disease progression and critical reviews have discussed the so-called 'danger theory' related to endometriosis. Hence, we performed immunoassays to evaluate whether local inflammation is linked to the severity of the disease. In addition, we investigated the role of recently described cytokines IL-33, IL-32α and the 'alarmin' high mobility group box 1 (HMGB1). We confirmed a dysfunctional immune response in the local environment of women suffering from endometriosis. However, we found no direct evidence for a significant up-regulation of danger signals in endometriosis, irrespective of the severity of the disease.

KEYWORDS:

DAMPs; Endometriosis; HMGB1; IL-33; Pro-inflammatory cytokines

PMID:
30099220
DOI:
10.1016/j.jri.2018.07.006

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