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Endocrinol Metab Clin North Am. 2018 Sep;47(3):577-601. doi: 10.1016/j.ecl.2018.04.009.

Gastrinomas: Medical or Surgical Treatment.

Author information

1
Department of Surgery, Stanford University School of Medicine, 291 campus Drive, Stanford, CA 94305-5101, USA.
2
Neuroendocrine Tumor Centra, Fukuoka Sanno Hospital, International University of Health and Welfare, 3-6-45 Momochihama, Sawara-Ku, Fukuoka 814-0001, Japan.
3
Digestive Diseases Branch, NIDDK, National Institutes of Health, Building 10, Room 9C-103, Bethesda, MD 20892-1804, USA. Electronic address: robertj@bdg10.niddk.nih.gov.

Abstract

This article reviews the role of surgical and medical management in patients with Zollinger-Ellison syndrome (ZES) due to a gastrin-secreting neuroendocrine tumor (gastrinoma). It concentrates on the status at present but also briefly reviews the changes over time in treatment approaches. Generally, surgical and medical therapy are complementary today; however, in some cases, such as patients with ZES and multiple endocrine neoplasia type 1, the treatment approach remains controversial.

KEYWORDS:

Acid secretion; Gastrinoma; Multiple endocrine neoplasia type 1; Neuroendocrine tumor; Proton pump inhibitors; Zollinger-Ellison syndrome

PMID:
30098717
PMCID:
PMC6092039
[Available on 2019-09-01]
DOI:
10.1016/j.ecl.2018.04.009
[Indexed for MEDLINE]

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