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Arch Gerontol Geriatr. 2018 Nov - Dec;79:39-44. doi: 10.1016/j.archger.2018.07.017. Epub 2018 Jul 29.

Assessment of risk factors for cerebrovascular disease among the elderly in Beijing: A 23-year community-based prospective study in China.

Author information

1
Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China; Beijing Municipal Key Laboratory of Clinical Epidemiology, Capital Medical University, Beijing, China.
2
Greenwood Medical Company, 300 Highway Burwood, Melbourne, Victoria, Australia.
3
Global Health and Genomics, School of Medical Sciences and Health, Edith Cowan University, Perth, Western Australia, Australia.
4
Department of Mathematics and Statistics, La Trobe University, Victoria, Australia.
5
Beijing Geriatric Healthcare Center, Xuan Wu Hospital, Capital Medical University, Beijing, China. Electronic address: tangzhe@medmail.com.cn.
6
Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China; Beijing Municipal Key Laboratory of Clinical Epidemiology, Capital Medical University, Beijing, China. Electronic address: statguo@ccmu.edu.cn.

Abstract

INTRODUCTION:

There are few studies on how lifestyle factors and mental conditions modulate the cerebrovascular diseases (CBVD) mortality risk are rare in the Asian elderly.

AIM:

To comprehensively assess the impact of lifestyle factors and mental conditions on the mortality risk of CBVD among the Chinese older adults.

MATERIAL AND METHODS:

This community-based prospective cohort study was based on the Beijing Longitudinal Study of Aging. We included 2101 participants aged ≥55 years who were interviewed in August 1992 and followed until December 2015. Baseline sociodemographic variables, lifestyle behaviors, and medical conditions were collected using a standard questionnaire. In addition, biochemical parameters, the Activities of Daily Living (ADL) scale, Center for Epidemiological Studies Depression (CES-D) scale, and Mini-Mental State Examination (MMSE) were performed. Hazard ratio (HR) and 95% confidence intervals (CI) was estimated from the competing risk model.

RESULTS:

During the follow-up period, 576 (27.42%) CBVD events were documented. Multivariable analysis showed that hypertension (HR = 2.331, 95% CI = 1.652-3.288,P < 0.001), depression (HR=2.331, 95% CI=1.652-3.288, P < 0.001), cognitive impairment (HR=1.382, 95% CI=1.132-1.689, P < 0.001), and coronary heart diseases (HR=1.360, 95% CI=1.095-1.689, P = 0.005) were independently associated with CBVD, while body mass index, fasting blood glucose, triglycerides, drinking, and smoking were not associated with CBVD (all P > 0.05).

CONCLUSIONS:

Males were at higher risk of CBVD than females. Age, gender, hypertension, cognitive impairment, and depression were associated with CBVD among the elderly in Beijing, China.

KEYWORDS:

Cerebrovascular diseases; Mortality; Risk factors; Survival

PMID:
30096587
DOI:
10.1016/j.archger.2018.07.017
[Indexed for MEDLINE]

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