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Eur J Obstet Gynecol Reprod Biol. 2018 Oct;229:15-19. doi: 10.1016/j.ejogrb.2018.08.001. Epub 2018 Aug 2.

Prevalence of vitamin D deficiency in infertile women with polycystic ovarian syndrome and its association with metabolic syndrome - A prospective observational study.

Author information

1
Reproductive Medicine Unit, Christian Medical College Hospital, Vellore, India.
2
Department of Biostatistics, Christian Medical College Hospital, Vellore, India.
3
Reproductive Medicine Unit, Christian Medical College Hospital, Vellore, India. Electronic address: dockamz@gmail.com.

Abstract

OBJECTIVE:

The main purpose of this study was to determine the prevalence of vitamin D deficiency in infertile women with polycystic ovarian syndrome (PCOS) and to explore the association of hypovitaminosis D with metabolic syndrome in women with PCOS.

STUDY DESIGN:

A prospective observational study was conducted in a tertiary care, infertility centre from March 2016 to March 2017. The primary outcome was estimation of the prevalence of vitamin D deficiency in infertile PCOS women. Secondary outcomes were to study the association of hypovitaminosis D with metabolic syndrome, obesity and hypercholesterolemia in PCOS patients.

RESULTS:

A total of 256 infertile women with PCOS were included in the study. Vitamin D deficiency was observed in 70.3% women, 20.3% were vitamin D insufficient and only 9.4% were vitamin D sufficient. Metabolic syndrome was seen in 80/256 (31.25%) women. There was no evidence of an association between hypovitaminosis D and metabolic syndrome, obesity or hyperlipidemia. There was a strong evidence of an association between waist circumference of >80 cm and vitamin D deficiency (p = 0.02).

CONCLUSION:

Vitamin D deficiency is highly prevalent in infertile PCOS women and there seems to be no association between hypovitaminosis D and the metabolic syndrome in the same population.

KEYWORDS:

Hypovitaminosis D; Polycystic ovarian syndrome; Vitamin D

PMID:
30096464
DOI:
10.1016/j.ejogrb.2018.08.001
[Indexed for MEDLINE]

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