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J Addict Med. 2018 Aug 9. doi: 10.1097/ADM.0000000000000444. [Epub ahead of print]

Topiramate Treatment of Alcohol Use Disorder in Clinical Practice.

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University of Massachusetts Medical School, Worcester, MA (HJ-B); Massachusetts General Hospital, Boston, MA (LJ); and Yale University School of Medicine, New Haven, CT (HJ-B, AJA).


: Topiramate is an anticonvulsant medication with increasingly strong evidence, supporting its use for treating alcohol use disorder (AUD) based on clinical trials. These clinical cases summarize the initiation and titration of topiramate in AUD treatment. The core issues of patient selection, consideration of comorbid psychiatric and medical conditions, side-effect profile, safety and effectiveness are reviewed. Addiction physicians should take a leading role in using topiramate to treat AUDs, working with patients to balance the benefits of topiramate with the risk.

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