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Chem Commun (Camb). 2018 Aug 23;54(69):9611-9614. doi: 10.1039/c8cc05735d.

A domino reaction of 2-isocyanophenyloxyacrylate and aryne to synthesize arenes with vicinal olefin and benzoxazole.

Author information

1
School of Materials Science and Engineering, Shanghai University, 99 Shangda Road, Shanghai 200444, P. R. China. ylchen@staff.shu.edu.cn.

Abstract

An unusual domino reaction of 2-isocyanophenyloxyacrylate and aryne has been disclosed. The present strategy experiences nucleophilic addition, Michael addition, carbon-oxygen cleavage, and cyclization, thus enabling the quick aryne vicinal difunctionalization by the installation of a benzoxazole and an olefin.

PMID:
30094421
DOI:
10.1039/c8cc05735d

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