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Adv Med Sci. 2018 Sep;63(2):347-352. doi: 10.1016/j.advms.2018.04.011. Epub 2018 Aug 6.

Topical folinic acid enhances wound healing in rat model.

Author information

1
Department of Dermatology, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey. Electronic address: nilayduman@aku.edu.tr.
2
Department of Opthalmology, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey.
3
Department of Histology and Embryology, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey.
4
Department of General Surgery, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey.
5
Experimental Animal Research and Application Center, Afyon Kocatepe University, Afyonkarahisar, Turkey.
6
Department of Mechatronics Engineering, Faculty of Technology, Afyon Kocatepe University, Afyonkarahisar, Turkey.
7
Department of Chemical Engineering, Faculty of Engineering, Afyon Kocatepe University, Afyonkarahisar, Turkey.

Abstract

PURPOSE:

Folic acid is an essential vitamin participating in DNA synthesis and repair. Recently folic acid has been shown to stimulate DNA-repair capacity in dermal fibroblasts in response to injury. Thus, the present study aimed to investigate the effects of topical folinic acid, a 5-formyl derivative of tetrahydrofolic acid, on wound healing using rat wound model.

MATERIALS AND METHODS:

A rat wound model was established, and the wound healing was evaluated by macroscopic and histological analyses among vehicle control, 2.5% folinic acid, 1% folinic acid, and dexpanthenol treatment groups. While an image-analysis program was used to evaluate macroscopic wound closure, connective tissue properties, mast cell numbers, and the expressions of matrix metalloproteinase 1 (MMP-1) and 9 (MMP-9) were evaluated by microscopy.

RESULTS:

The 2.5% folinic acid-treated group exhibited enhanced wound healing by increased reepithelialization, neo-vessel formation, inflammatory cell migration, collagen deposition and progressive mast cell increase. Furthermore, 2.5% folinic acid induced higher expressions of MMP-1 and MMP-9.

CONCLUSIONS:

Folinic acid enhances both macroscopic and microscopic wound healing in rat wound model.

KEYWORDS:

Folinic acid; Rat; Wound healing

PMID:
30092503
DOI:
10.1016/j.advms.2018.04.011
[Indexed for MEDLINE]

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