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Epigenomics. 2018 Aug 9. doi: 10.2217/epi-2018-0080. [Epub ahead of print]

Integrated analysis of microfibrillar-associated proteins reveals MFAP4 as a novel biomarker in human cancers.

Yang J1,2, Song H3,4, Chen L5, Cao K6, Zhang Y7, Li Y1,2, Hao X1,2.

Author information

1
The State Key Laboratory of Functions & Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, PR China.
2
The Key Laboratory of Chemistry for Natural Products of Guizhou Province & Chinese Academic of Sciences, Guiyang 550014, PR China.
3
The Key Laboratory of Endemic & Ethnic Diseases, Guizhou Medical University, Ministry of Education, Guiyang 550004, PR China.
4
The Key Laboratory of Medical Molecular Biology, Guizhou Medical University, Guizhou Province, Guiyang 550004, PR China.
5
Guiyang University of Chinese Medicine, School of Pharmaceutical Sciences, Guiyang 550025, PR China.
6
Department of General Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang 550001, PR China.
7
Guizhou University, School of Pharmaceutical Sciences, Guiyang, 550025, PR China.

Abstract

AIM:

The potential functions and underlying mechanism of microfibrillar-associated proteins (MFAPs) are explored in human cancers.

MATERIALS & METHODS:

Here, we examined the expression profiles, prognostic values, epigenetic and genetic alterations of MFAPs in human cancers from public omics repository.

RESULTS:

Among MFAPs family, MFAP4 was frequently downregulated in the most human cancers and high mRNA expression of MFAP4 significantly correlated with better overall survival in breast cancer. DNA hypermethylation in the promoter of MFAP4 decreased its mRNA expression. MFAP4 strongly associated with pathway in impairment and alteration of the elastic fibers.

CONCLUSION:

This integrated analysis provides new insights into MFAPs in human cancers and indicates that MFAP4 could be used as novel biomarker for developing therapies against human cancers.

KEYWORDS:

DNA methylation; TCGA; breast cancer; microfibrillar-associated protein 4; overall survival

PMID:
30089404
DOI:
10.2217/epi-2018-0080

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