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Qual Life Res. 2018 Nov;27(11):2935-2944. doi: 10.1007/s11136-018-1958-5. Epub 2018 Aug 7.

Evaluating the PROMIS-29 v2.0 for use among older adults with multiple chronic conditions.

Author information

1
RAND Corporation, 20 Park Plaza, Suite 920, Boston, MA, 02116, USA. arose@rand.org.
2
Section of General Internal Medicine, Boston University School of Medicine, Boston, MA, USA. arose@rand.org.
3
Institute for Health Research, Kaiser Permanente Colorado, Aurora, CO, USA.
4
Department of Family Medicine, University of Colorado School of Medicine, Aurora, CO, USA.
5
RAND Corporation, Santa Monica, CA, USA.
6
RAND Corporation, 20 Park Plaza, Suite 920, Boston, MA, 02116, USA.

Abstract

PURPOSE:

The Patient-Reported Outcomes Measurement Information System 29-item profile (PROMIS-29 v2.0), which measures health-related quality of life (HRQoL), has had limited evaluation among older adults (age 65+) with multiple chronic conditions. Our purpose was to establish convergent validity for PROMIS-29 in this population.

METHODS:

We collected the PROMIS-29 v2.0 and the Veterans RAND 36 (VR-36) for 1359 primary care patients aged 65 + with at least 2 of 13 chronic conditions, oversampling those aged 80+. We conducted multiple analyses to examine score differences across subgroups, differential item functioning (DIF), and comparisons of PROMIS-29 v2.0 and VR-36 scores.

RESULTS:

The mean age was 80.7, and all patients had at least 2 of 13 chronic conditions. Older age, female sex, Hispanic ethnicity, and more chronic conditions were associated with worse physical health scores (PHS) and mental health scores (MHS) on the PROMIS-29 v2.0-findings which are in the expected direction. None of the 700 pairs of items met criteria for DIF. PHS and MHS were highly intercorrelated (r = 0.74, p < 0.001 for this and all other findings). PHS was more highly correlated with the VR-36 Physical Component Score (PCS) than the Mental Component Score (MCS) (r = 0.85 and 0.32, respectively), while MHS was highly correlated with both (r = 0.70 and 0.64, respectively).

CONCLUSIONS:

PROMIS-29 v2.0 demonstrates expected bivariate relationships with key person-level characteristics and does not show DIF. PROMIS-29 v2.0 scores are highly correlated with VR-36 scores. These results provide support for the validity of PROMIS-29 v2.0 as a measure of HRQoL among older adults with multiple chronic conditions.

KEYWORDS:

Chronic disease; Comorbidity; Elderly; Geriatrics; PROMIS; Quality of life

PMID:
30088121
PMCID:
PMC6196113
[Available on 2019-11-01]
DOI:
10.1007/s11136-018-1958-5
[Indexed for MEDLINE]

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