Format

Send to

Choose Destination
J Biomed Sci. 2018 Aug 7;25(1):61. doi: 10.1186/s12929-018-0463-z.

Genetic influence alters the brain synchronism in perception and timing.

Author information

1
Neuro-innovation Technology & Brain Mapping Laboratory, Federal University of Piauí, Av. São Sebastião n° 2819 - Nossa Sra. de Fátima -, Parnaíba, PI, CEP 64202-020, Brazil. victormarinhophb@hotmail.com.
2
Genetics and Molecular Biology Laboratory, Federal University of Piauí, Parnaíba, Brazil. victormarinhophb@hotmail.com.
3
The Northeast Biotechnology Network (RENORBIO), Federal University of Piauí, Teresina, Brazil. victormarinhophb@hotmail.com.
4
Neuro-innovation Technology & Brain Mapping Laboratory, Federal University of Piauí, Av. São Sebastião n° 2819 - Nossa Sra. de Fátima -, Parnaíba, PI, CEP 64202-020, Brazil.
5
Genetics and Molecular Biology Laboratory, Federal University of Piauí, Parnaíba, Brazil.
6
The Northeast Biotechnology Network (RENORBIO), Federal University of Piauí, Teresina, Brazil.
7
Brain Mapping and Sensory Motor Integration Laboratory, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
8
Master's Program in Local Development Program, University Center Augusto Motta - UNISUAM, Rio de Janeiro, Brazil and Health Sciences Applied - Vassouras University, Rio de Janeiro, Brazil.
9
Brain Mapping and Functionality Laboratory, Federal University of Piauí, Parnaíba, Brazil.
10
Department of Biology, Camden County College, Blackwood, NJ, USA.

Abstract

BACKGROUND:

Studies at the molecular level aim to integrate genetic and neurobiological data to provide an increasingly detailed understanding of phenotypes related to the ability in time perception.

MAIN TEXT:

This study suggests that the polymorphisms genetic SLC6A4 5-HTTLPR, 5HTR2A T102C, DRD2/ANKK1-Taq1A, SLC6A3 3'-UTR VNTR, COMT Val158Met, CLOCK genes and GABRB2 A/C as modification factor at neurochemical levels associated with several neurofunctional aspects, modifying the circadian rhythm and built-in cognitive functions in the timing. We conducted a literature review with 102 studies that met inclusion criteria to synthesize findings on genetic polymorphisms and their influence on the timing.

CONCLUSION:

The findings suggest an association of genetic polymorphisms on behavioral aspects related in timing. However, order to confirm the paradigm of association in the timing as a function of the molecular level, still need to be addressed future research.

KEYWORDS:

Circadian rhythm; Dopamine; GABA; Genetic polymorphisms; Serotonin; Time perception

PMID:
30086746
PMCID:
PMC6080374
DOI:
10.1186/s12929-018-0463-z
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for BioMed Central Icon for PubMed Central
Loading ...
Support Center