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BMC Infect Dis. 2018 Aug 7;18(1):381. doi: 10.1186/s12879-018-3284-5.

Severe epidemic myalgia with an elevated level of serum interleukin-6 caused by human parechovirus type 3: a case report and brief review of the literature.

Author information

1
Department of Infection Control, Fukushima Medical University, 1 Hikarigaoka, Fukushima, 960-1295, Japan. kinakamu@fmu.ac.jp.
2
Ikeda Memorial Hospital, Sukagawa, Japan. kinakamu@fmu.ac.jp.
3
Department of Infection Control, Fukushima Medical University, 1 Hikarigaoka, Fukushima, 960-1295, Japan.
4
Department of Infection Control and Laboratory Diagnostics, Tohoku University Graduate School of Medicine, Sendai, Japan.
5
Department of Microbiology, Fukushima Prefectural Institute of Public Health, Fukushima, Japan.
6
Department of Microbiology, St. Marianna University School of Medicine, Kawasaki, Japan.
7
Ikeda Memorial Hospital, Sukagawa, Japan.

Abstract

BACKGROUND:

Human parechovirus type 3 (HPeV-3) is known to cause cold-like symptoms, diarrhea, or severe infections such as sepsis in infants and children. In adults, HPeV-3 infection is rarely diagnosed because the symptoms are generally mild and self-limiting; however, this infection has been linked to epidemic myalgia, regardless of the presence of underlying diseases, immunosuppression, or sex.

CASE PRESENTATION:

We describe an adult case of severe systemic myalgia and orchiodynia after infection with HPeV-3, which was transmitted from the child of the patient. Interleukin-6 (IL-6) level was found to be elevated in the patient's serum.

CONCLUSION:

Severe myalgia associated with HPeV-3 infection is potentially caused by an elevated serum level of IL-6.

KEYWORDS:

Epidemic myalgia; Human parechovirus type 3; IL-6; Orchiodynia

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