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J Pediatric Infect Dis Soc. 2018 Jul 31. doi: 10.1093/jpids/piy069. [Epub ahead of print]

Clinical Manifestations and Bacterial Genomic Analysis of Group A Streptococcus Strains That Cause Pediatric Toxic Shock Syndrome.

Author information

1
Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston.
2
Division of Infectious Diseases, Department of Pediatrics, Center for Antimicrobial Resistance and Microbial Genomics, McGovern Medical School, University of Texas Health Sciences Center at Houston.
3
Section of Infectious Diseases, Baylor College of Medicine and Texas Children's Hospital, Houston.

Abstract

We report here 18 cases of pediatric group A streptococcal toxic shock syndrome, associated clinical findings, and bacterial molecular genetic characteristics discovered through whole-genome sequencing. This comparative whole-genome sequencing revealed unique gene content (speK) and polymorphisms (dpiB) in emm87 group A Streptococcus, the relative contributions of which, in combination with the host response, in the development of streptococcal toxic shock syndrome remain to be elucidated.

PMID:
30085250
DOI:
10.1093/jpids/piy069

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