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Aesthet Surg J. 2018 Jul 31. doi: 10.1093/asj/sjy185. [Epub ahead of print]

Safety and Efficacy of a Scar Cream Consisting of Highly Selective Growth Factors Within a Silicone Cream Matrix: A Double-Blinded, Randomized, Multicenter Study.

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Keck School of Medicine, University of Southern California, Los Angeles, CA.
Private Oculoplastic Surgery Practice in Los Angeles, CA.
Department of Plastic Surgery, UCLA David Geffen School of Medicine, Los Angeles, CA.
Dermatology Service, Memorial Sloan Kettering Center, New York, NY.
Department of Plastic Surgery, Loma Linda University Medical Center, Loma Linda, CA.



Several growth factors and hyaluronic acid (HA) are implicated in fetal scarless healing. Whether these factors can be applied toward an adult scar to improve scar characteristics is unknown.


This study compared the efficacy and safety of SKN2017B, a proprietary topical cream consisting of selective synthetic recombinant human growth factors and HA in a silicone base with a specifically formulated silicone cream for postsurgical scar treatment.


In this prospective, randomized, controlled, double-blinded study, unilateral or bilateral facial or truncal scars in adult surgical patients were randomly treated with SKN2017B or silicone cream. Study investigators, study subjects, and 2 independent reviewers assessed improvement in scar characteristics after 4 and 12 weeks of treatment.


Forty-nine bilateral and 12 unilateral scars in 45 subjects were treated with SKN2017B or silicone. At 12 weeks, investigators rated 74% of scars treated with SKN2017B to have shown overall improvement versus 54% of silicone-treated scars; a 73% relative improvement with SKN2017B (P < 0.0001). Subjects rated a moderate-to-significant improvement in 85% of SKN2017B-treated scars versus 51% of silicone-treated scars, a 67% relative improvement with SKN2017B (P < 0.001). Independent reviewers rated 87% of scars treated with SKN2017B to be better overall versus 1% of scars treated with silicone (P < 0.0001). There were no tolerability issues or adverse reactions with either cream.


SKN2017B consisting of highly selective growth factors within a silicone cream matrix is well tolerated and effective for surgical scar management.


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