Format

Send to

Choose Destination
Nat Immunol. 2018 Sep;19(9):963-972. doi: 10.1038/s41590-018-0176-1. Epub 2018 Aug 6.

Epigenetic control of innate and adaptive immune memory.

Author information

1
Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
2
Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
3
Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. sunj@mskcc.org.
4
Department of Immunology and Microbial Pathogenesis, Weill Cornell Medical College, New York, NY, USA. sunj@mskcc.org.

Abstract

Clonal expansion and immunological memory are hallmark features of the mammalian adaptive immune response and essential for prolonged host control of pathogens. Recent work demonstrates that natural killer (NK) cells of the innate immune system also exhibit these adaptive traits during infection. Here we demonstrate that differentiating and 'memory' NK cells possess distinct chromatin accessibility states and that their epigenetic profiles reveal a 'poised' regulatory program at the memory stage. Furthermore, we elucidate how individual STAT transcription factors differentially control epigenetic and transcriptional states early during infection. Finally, concurrent chromatin profiling of the canonical CD8+ T cell response against the same infection demonstrated parallel and distinct epigenetic signatures defining NK cells and CD8+ T cells. Overall, our study reveals the dynamic nature of epigenetic modifications during the generation of innate and adaptive lymphocyte memory.

PMID:
30082830
PMCID:
PMC6225771
DOI:
10.1038/s41590-018-0176-1
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center