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Semin Nephrol. 2018 Jul;38(4):336-345. doi: 10.1016/j.semnephrol.2018.05.004.

Personalized Approach and Precision Medicine in Supportive and End-of-Life Care for Patients With Advanced and End-Stage Kidney Disease.

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Division of Nephrology and Immunology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.. Electronic address:


Kidney supportive care requires a highly personalized approach to care. Precision medicine holds promise for a deeper understanding of the pathophysiology of symptoms and related syndromes and more precise individualization of prognosis and treatment estimates, therefore providing valuable opportunities for greater personalization of supportive care. However, the major drivers of quality of life are psychosocial, economic, lifestyle, and preference-based, and consideration of these factors and skilled communication are integral to the provision of excellent and personalized kidney supportive care. This article discusses the concepts of personalized and precision medicine in the context of kidney supportive care and highlights some opportunities and limitations within these fields.


Precision medicine; end-stage kidney disease; kidney supportive care; personalized medicine; prognosis; symptom management

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