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Mar Drugs. 2018 Aug 4;16(8). pii: E273. doi: 10.3390/md16080273.

Chitosan-Based Composite Materials for Prospective Hemostatic Applications.

Author information

1
Department of Applied Chemistry, School of Chemistry and Environmental Science, Guangdong Ocean University, Zhanjiang 524088, Guangdong, China. huzhangqyx@126.com.
2
Department of Applied Chemistry, School of Chemistry and Environmental Science, Guangdong Ocean University, Zhanjiang 524088, Guangdong, China. 17875128648@163.com.
3
Department of Applied Chemistry, School of Chemistry and Environmental Science, Guangdong Ocean University, Zhanjiang 524088, Guangdong, China. smelilst@163.com.
4
Agricultural Product Processing Research Institute, Chinese Academy of Tropical Agricultural Sciences, Zhanjiang 524001, Guangdong, China. puwangli@163.com.
5
Department of Applied Chemistry, School of Chemistry and Environmental Science, Guangdong Ocean University, Zhanjiang 524088, Guangdong, China. sidongligdou@163.com.

Abstract

Effective hemostasis is vital to reduce the pain and mortality of patients, and the research and development of hemostatic materials are prerequisite for effective hemostasis. Chitosan (CS), with good biodegradability, biocompatibility and non-toxicity, has been widely applied in bio-medicine, the chemical industry, the food industry and cosmetics. The excellent hemostatic properties of CS have been extensively studied. As a result, chitosan-based composite hemostatic materials have been emerging. In this review, the hemostatic mechanism of chitosan is briefly discussed, and then the progress of research on chitosan-based composite hemostatic materials with multiple forms such as films, sponges, hydrogels, particles and fibers are introduced. Finally, future perspectives of chitosan-based composite hemostatic materials are given. The objective of this review is to provide a reference for further research and development of effective hemostatic materials.

KEYWORDS:

applications; chitosan; composite materials; fibers; films; hemostasis; hydrogels; mechanisms; particles; sponges

PMID:
30081571
PMCID:
PMC6117657
DOI:
10.3390/md16080273
[Indexed for MEDLINE]
Free PMC Article

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