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Chem Commun (Camb). 2018 Aug 21;54(68):9442-9445. doi: 10.1039/c8cc03614d.

HMGB1 binds to the KRAS promoter G-quadruplex: a new player in oncogene transcriptional regulation?

Author information

1
Department of Pharmacy, University of Naples "Federico II", Via D. Montesano 49, 80131 Naples, Italy. bruno.pagano@unina.it.

Abstract

This communication reports on a possible distinct role of HMGB1 protein. Biophysical studies revealed that HMGB1 binds and stabilizes the G-quadruplex of the KRAS promoter element that is responsible for most of the transcriptional activity. Biological data showed that inhibition of HMGB1 increases KRAS expression. These results suggest that HMGB1 could play a role in the gene transcriptional regulation via the functional recognition of the G-quadruplex.

PMID:
30079419
PMCID:
PMC6234227
[Available on 2019-08-21]
DOI:
10.1039/c8cc03614d
[Indexed for MEDLINE]

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