Format

Send to

Choose Destination
Front Cell Dev Biol. 2018 Jul 20;6:80. doi: 10.3389/fcell.2018.00080. eCollection 2018.

Mouse Yolk Sac Hematopoiesis.

Author information

1
Department of Stem Cell and Developmental Biology, Mie University Graduate School of Medicine, Tsu, Japan.

Abstract

The yolk sac is the first observed site of hematopoiesis during mouse ontogeny. Primitive erythroid cells are the most well-recognized cell lineages produced from this tissue. In addition to primitive erythroid cells, several types of hematopoietic cells are present, including multipotent hematopoietic progenitors. Yolk sac-derived blood cells constitute a transient wave of embryonic and fetal hematopoiesis. However, recent studies have demonstrated that some macrophage and B cell lineages derived from the early yolk sac may persist to adulthood. This review discusses the cellular basis of mouse yolk sac hematopoiesis and its contributions to embryonic and adult hematopoietic systems.

KEYWORDS:

B-1 B cell; blood cell development; embryonic hematopoiesis; fetal hematopoiesis; macrophage; yolk sac

Supplemental Content

Full text links

Icon for Frontiers Media SA Icon for PubMed Central
Loading ...
Support Center