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Curr Opin Neurobiol. 2018 Dec;53:131-138. doi: 10.1016/j.conb.2018.07.006. Epub 2018 Aug 2.

Regulation of neurogenesis in the adult and aging brain.

Author information

1
Perception and Memory Lab, Neuroscience Department, Institut Pasteur, Paris, France; Centre National de la Recherche Scientifique, Unité Mixte de Recherche 3571, F-75015 Paris, France. Electronic address: lida.katsimpardi@pasteur.fr.
2
Perception and Memory Lab, Neuroscience Department, Institut Pasteur, Paris, France; Centre National de la Recherche Scientifique, Unité Mixte de Recherche 3571, F-75015 Paris, France. Electronic address: pmlledo@pasteur.fr.

Abstract

Neural stem cells (NSCs) represent a remarkable developmental unit, necessary for the proper functioning of neurogenesis, by retaining their plasticity to self-renew and give rise to progeny throughout life in specific regions of the adult brain. Although NSCs were thought to merely represent a stem cell type in the brain, recent advances have demonstrated the incredible complexity of NSC identity and functions. Ranging between quiescence, activation and intermediary subtypes, NSCs choose their fate through their developmental inheritance, regional positioning within the niche, as well as dynamic transcriptional and metabolic states. The plasticity of their developmental program is reflected in the tremendous changes they undergo upon external environmental cues and extrinsic manipulations, and harnessing these potentials can open new avenues to fight against brain injury, neurodegenerative and age-related diseases.

PMID:
30077888
DOI:
10.1016/j.conb.2018.07.006
[Indexed for MEDLINE]
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