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Cell Immunol. 2018 Sep;331:161-167. doi: 10.1016/j.cellimm.2018.06.007. Epub 2018 Jun 22.

Skewed balance of regulatory T cell and inflammatory T cell in IL-17 defect with human metapneumovirus infection.

Author information

1
Children's Hospital of Chongqing Medical University, Chongqing 400014, China.
2
Research Center for Immunologic and Infectious Diseases, Children's Hospital of Chongqing Medical University, Chongqing 400014, China; Division of Immunology, Children's Hospital of Chongqing Medical University, Chongqing 400014, China; Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Chongqing 400014, China.
3
Division of Flow Cytometry, Children's Hospital of Chongqing Medical University, Chongqing 400014, China.
4
Division of Pathology, Children's Hospital of Chongqing Medical University, Chongqing 400014, China.
5
Division of Respiratory, Children's Hospital of Chongqing Medical University, Chongqing 400014, China.
6
General Medical Wards, Children's Hospital of Chongqing Medical University, Chongqing 400014, China.
7
General Medical Wards, Children's Hospital of Chongqing Medical University, Chongqing 400014, China. Electronic address: xinchen_19@hotmail.com.

Abstract

Human metapneumovirus (hMPV) is a common cause of respiratory infections in children. However, the precise mechanisms underlying the development of hMPV-induced pulmonary pathology remain unknown. Studies show that IL-17 plays an important role in some inflammatory diseases of the airways, including asthma and chronic obstructive pulmonary disease. Here, we generated an IL-17 KO murine model of hMPV infection and used it to characterize the role of IL-17 hMPV-induced pulmonary inflammation. The results demonstrated that the defect in IL-17 resulted in less neutrophil influx into the lungs, along with reduced ventilatory function. Meanwhile, viral infection in IL-17 KO mice increased regulatory T cells (Tregs) and reduced Th1 and Th2 cells in the lung, suggesting that lack of IL-17 skews the immune response in the lung toward an anti-inflammatory profile, as exhibited by a greater number of Treg cells and fewer Th1 and Th2 cells.

KEYWORDS:

Foxp3; IFN-γ; IL-17; IL-4; hMPV

PMID:
30077332
DOI:
10.1016/j.cellimm.2018.06.007
[Indexed for MEDLINE]

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