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Phytochemistry. 2018 Nov;155:61-68. doi: 10.1016/j.phytochem.2018.07.017. Epub 2018 Aug 1.

Truncateols O-V, further isoprenylated cyclohexanols from the sponge-associated fungus Truncatella angustata with antiviral activities.

Author information

1
State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, People's Republic of China.
2
Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine University, 40225 Duesseldorf, Germany.
3
State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, People's Republic of China. Electronic address: whlin@bjmu.edu.cn.

Abstract

Chemical examination of the EtOAc extract of the sponge-associated fungus Truncatella angustata in solid culture led to the isolation of eight undescribed isoprenylated cyclohexanols, namely truncateols O-V together with 14 known analogues. Their structures were determined on the basis of extensive spectroscopic analyses, including the modified Mosher's method and ECD data for the assignment of their absolute configurations. Truncateol O exhibited significant inhibition toward both HIV-1 and H1N1 virus, while truncateol P exerted inhibitory effect against HIV-1 virus.

KEYWORDS:

Amphisphaeriaceae; Anti-H(1)N(1) activity; Anti-HIV-1 activity; Marine-derived fungus; Truncatella angustata; Truncateols O-V

PMID:
30077121
DOI:
10.1016/j.phytochem.2018.07.017
[Indexed for MEDLINE]

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