Format

Send to

Choose Destination
Magn Reson Imaging. 2018 Dec;54:218-224. doi: 10.1016/j.mri.2018.07.016. Epub 2018 Aug 2.

Subcortical brain iron deposition and cognitive performance in older women with breast cancer receiving adjuvant chemotherapy: A pilot MRI study.

Author information

1
Department of Diagnostic Radiology, City of Hope National Medical Center, Duarte, CA, United States; Center for Cancer and Aging, City of Hope National Medical Center, Duarte, CA, United States. Electronic address: Bechen@coh.org.
2
Magnetic Resonance Innovations, Inc., Detroit, MI, United States.
3
Department of Diagnostic Radiology, City of Hope National Medical Center, Duarte, CA, United States.
4
Department of Population Science, City of Hope National Medical Center, Duarte, CA, United States.
5
Center for Cancer and Aging, City of Hope National Medical Center, Duarte, CA, United States.
6
Division of Mathematical Oncology, City of Hope National Medical Center, Duarte, CA, United States.
7
Magnetic Resonance Innovations, Inc., Detroit, MI, United States; Department of Biomedical Engineering, Wayne State University, Detroit, MI, United States.
8
Neurocognitive Research Lab, Memorial Sloan Kettering Cancer Center, New York, NY, United States.
9
Center for Neuroimaging, Indiana University School of Medicine, Indianapolis, IN, United States.
10
Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY, United States.
11
Division of Neurology, City of Hope National Medical Center, Duarte, CA, United States.
12
Department of Medical Oncology, City of Hope National Medical Center, Duarte, CA, United States.
13
Center for Cancer and Aging, City of Hope National Medical Center, Duarte, CA, United States; Department of Medical Oncology, City of Hope National Medical Center, Duarte, CA, United States.

Abstract

As the number of older adults in the U.S. increases, so too will the incidence of cancer and cancer-related cognitive impairment (CRCI). However, the exact underlying biological mechanism for CRCI is not yet well understood. We utilized susceptibility-weighted imaging with quantitative susceptibility mapping, a non-invasive MRI-based technique, to assess longitudinal iron deposition in subcortical gray matter structures and evaluate its association with cognitive performance in women age 60+ with breast cancer receiving adjuvant chemotherapy and age-matched women without breast cancer as controls. Brain MRI scans and neurocognitive scores from the NIH Toolbox for Cognition were obtained before chemotherapy (time point 1) and within one month after the last infusion of chemotherapy for the patients and at matched intervals for the controls (time point 2). There were 14 patients age 60+ with breast cancer (mean age 66.3 ± 5.3 years) and 13 controls (mean age 68.2 ± 6.1 years) included in this study. Brain iron increased as age increased. There were no significant between- or within- group differences in neurocognitive scores or iron deposition at time point 1 or between time points 1 and 2 (p > 0.01). However, there was a negative correlation between iron in the globus pallidus and the fluid cognition composite scores in the control group at time point 1 (r = -0.71; p < 0.01), but not in the chemotherapy group. Baseline iron in the putamen was negatively associated with changes in the oral reading recognition scores in the control group (r = 0.74, p < 0.01), but not in the chemotherapy group. Brain iron assessment did not indicate cancer or chemotherapy related short-term differences, yet some associations with cognition were observed. Studies with larger samples and longer follow-up intervals are warranted.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT01992432.

KEYWORDS:

Brain iron; Breast cancer; Cancer-related cognitive impairment (CRCI); Chemotherapy; Gray matter nucleus; Quantitative susceptibility mapping (QSM)

PMID:
30076946
PMCID:
PMC6298788
[Available on 2019-12-01]
DOI:
10.1016/j.mri.2018.07.016
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center