Format

Send to

Choose Destination
Exp Cell Res. 2018 Sep 15;370(2):190-197. doi: 10.1016/j.yexcr.2018.07.046. Epub 2018 Jul 31.

Roles of genetic and microenvironmental factors in cancer epithelial-to-mesenchymal transition and therapeutic implication.

Author information

1
Department of Immunology, Basic Medical School, Guizhou Medical University, Guiyang 550004, China. Electronic address: yangliuqi500@sina.com.
2
Department of Immunology, Basic Medical School, Guizhou Medical University, Guiyang 550004, China.

Abstract

Epithelial-to-mesenchymal transition (EMT) is a process in which epithelial cells lose their cell-cell contacts resulting in the formation of mesenchymal cells with migratory properties. Increasing evidence indicate EMT plays a key role in the invasion, metastasis and therapeutic resistance of cancer and maintenance of the phenotype of cancer stem cells (CSCs), which makes the prognosis of patients worse. The progression of cancer from epithelial tissue towards a malignant phenotype is driven by multiple factors that remodel the tissue architecture. This review summarizes and analyzes current studies of genetic and microenvironmental factors in inducing and maintaining cancer EMT and therapeutic implications. This will enable a better understanding of the contribution of EMT-associated factors to cancer progression and highlights that genetic factors and tumor microenvironment responsible for EMT could be used as attractive targets for therapeutic intervention.

KEYWORDS:

Epithelial-to-mesenchymal transition; Genetic factors; Therapy; Tumor microenvironment

PMID:
30075173
DOI:
10.1016/j.yexcr.2018.07.046
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center