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J Pediatr Gastroenterol Nutr. 2019 Jan;68(1):13-16. doi: 10.1097/MPG.0000000000002115.

Recent Prescription Patterns for Children With Acute Infectious Diarrhea.

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Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA.
Department of Social Medicine, National Center for Child Health and Development, Tokyo, Japan.
Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, Tokyo, Japan.
Division of Infectious Diseases, National Center for Child Health and Development, Tokyo, Japan.
Department of Microbiology, Immunology, and Biochemistry, University of Tennessee Health Science Center, Memphis, TN.
Department of Health Services Research, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Graduate School of Public Health, St. Luke's International University, Tokyo, Japan.



This study investigated recent trends in antibiotic use and factors associated with antibiotic use among children with acute infectious diarrhea. We obtained records of outpatients aged under 18 years diagnosed with acute infectious diarrhea from the Japan Medical Data Center database during 2012-2015.


We investigated prescription patterns of antibiotics at their initial visit and evaluated factors associated with antibiotic usage using multivariable log-binomial regression models.


Overall, we identified 4493 patients diagnosed with acute infectious diarrhea; 29.6% received antibiotics. The most commonly prescribed antibiotic is fosfomycin (20.3%). In multivariable log-binomial regression analysis, out-of-hour visits, clinical diagnoses of suspected bacterial enterocolitis, private outpatient clinics, and pediatric departments are significantly associated with higher prevalence of antibiotic use.


Antibiotics are over-prescribed for children with acute infectious diarrhea. Our investigation provides important information to promote education of physicians and of health policy considerations for appropriate antibiotic prescription practices.

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