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Curr Med Sci. 2018 Feb;38(1):174-183. doi: 10.1007/s11596-018-1862-9. Epub 2018 Mar 15.

B Vitamins Can Reduce Body Weight Gain by Increasing Metabolism-related Enzyme Activities in Rats Fed on a High-Fat Diet.

Author information

1
Department of Nutrition, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, China.
2
Institute of Human Nutrition, Medical College of Qingdao University, Qingdao, 266021, China. jasmine.maki@163.com.
3
Department of Pediatrics, Guilin Medical College Affiliated Hospital, Guilin, 541001, China. zhengmc_cn@163.com.
4
Institute of Human Nutrition, Medical College of Qingdao University, Qingdao, 266021, China.
5
Division of Human Nutrition, Wageningen University, Wageningen, 6700 EV, The Netherlands.

Abstract

B vitamins are enzyme cofactors that play an important role in energy metabolism. The aim of this study was to elucidate whether B vitamin administration can reduce body weight (BW) gain by improving energy metabolism-related enzyme activities in rats fed on a highfat diet. Fifty rats were randomly assigned to one of the following five groups: control group (C), including rats fed on standard rat chow; four treatment groups (HO, HI, H2, and H3), in which rats were fed on a high-fat diet. Rats in the HI group were treated daily with 100 mg/kg BW thiamine (VB1), 100 mg/kg BW riboflavin (VB2), and 250 mg/kg BW niacin (VPP); rats in the H2 group were treated daily with 100 mg/kg BW pyridoxine (VB6), 100 mg/kg BW cobalamin (VB12), and 5 mg/kg BW folate (FA); and rats in the H3 group were treated daily with all of the B vitamins administered to the HI and H2 groups. After 12 weeks, the BW gains from the initial value were 154.5±58.4 g and 159.1±53.0 g in the HI and C groups, respectively, which were significantly less than the changes in the HO group (285.2±14.8 g, P<0.05). In the HO group, the plasma total cholesterol (CHO) and triglyceride (TG) levels were 1.59±0.30 mmol/L and 1,55±0.40 mmol/L, respectively, which were significantly greater than those in the HI group (1.19±0.18 mmol/L and 0.76±0.34 mmol/L, respectively, P<0.05). The activities of transketolase (TK), glutathione reductase, and Na+/K+ adenosine triphosphatase were significantly increased in the B vitamin-treated groups and were significantly greater than those in the HO group (P<0.05). Furthermore, the glucose-6-phosphate dehydrogenase, pyruvic acid kinase, and succinate dehydrogenase activities also were increased after treatment with B vitamins. Supplementation with B vitamins could effectively reduce BW gain and plasma levels of lipids by improving energy metabolism-related enzyme activities in rats, thus possibly providing potential benefits to humans.

KEYWORDS:

B vitamins; body weight gain; enzyme activities; obesity; rats

PMID:
30074168
DOI:
10.1007/s11596-018-1862-9
[Indexed for MEDLINE]

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