Format

Send to

Choose Destination
HLA. 2018 Oct;92(4):199-205. doi: 10.1111/tan.13358.

HLA common and well-documented alleles in China.

He Y1,2, Li J3, Mao W4, Zhang D5, Liu M6, Shan X7, Zhang B8, Zhu C9, Shen J10, Deng Z11, Wang Z12, Yu W13, Chen Q14, Guo W15, Su P16, Lv R17, Li G18, Li G19, Pei B20, Jiao L21, Shen G22, Liu Y23, Feng Z24, Su Y25, Xie Y26, Di W27, Liu X28, Yang X29, Wang J14, Qi J6, Liu Q30, Han Y30, He J31, Cai J32,33, Zhang Z7, Zhu F1,2, Du D30.

Author information

1
HLA Laboratory, Blood Center of Zhejiang Province, Hangzhou, China.
2
HLA Laboratory, Key Laboratory of Blood Safety Research of Zhejiang Province, Hangzhou, China.
3
HLA Laboratory, Liaoning Blood Center, Shenyang, China.
4
HLA Laboratory, Chongqing Blood Center, Chongqing, China.
5
HLA Laboratory, Taiyuan Red Cross Blood Center, Taiyuan, China.
6
HLA Laboratory, Shanxi Blood Center, Xi'an, China.
7
HLA Laboratory, Beijing Red Cross Blood Center, Beijing, China.
8
HLA Laboratory, Henan Blood Center, Zhengzhou, China.
9
HLA Laboratory, Shandong Blood Center, Jinan, China.
10
HLA Laboratory, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
11
The Key Laboratory of Histocompatibility and Immunogenetics, Shenzhen Blood Center, Shenzhen, China.
12
HLA Laboratory, Hebei Blood Center, Shijiazhuang, China.
13
HLA Laboratory, Dalian Red Cross Blood Center, Dalian, China.
14
HLA Laboratory, Institute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College, Chengdu, China.
15
HLA Laboratory, Xinjiang Blood Center, Ürümqi, China.
16
HLA Laboratory, Kunming Blood Center, Kunming, China.
17
HLA Laboratory, Hefei Red Cross Blood Center, Hefei, China.
18
HLA Laboratory, Gansu Red Cross Blood Center, Lanzhou, China.
19
HLA Laboratory, Jiangxi Blood Center, Nanchang, China.
20
HLA Laboratory, Xiamen Blood Center, Xiamen, China.
21
HLA Laboratory, Changchun Blood Center, Changchun, China.
22
HLA Laboratory, Wuhan Blood Center, Wuhan, China.
23
HLA Laboratory, Harbin Red Cross Blood Center, Harbin, China.
24
HLA Laboratory, Qingdao Blood Center, Qingdao, China.
25
HLA Laboratory, Yueyang Red Cross Blood Center, Yueyang, China.
26
HLA Laboratory, Changsha Blood Center, Changsha, China.
27
HLA Laboratory, Soochow Red Cross Blood Center, Suzhou, China.
28
HLA Laboratory, CapitalBio Corporation, Beijing, China.
29
HLA Laboratory, Beijing Genomics Institute, Shenzhen, China.
30
Department of Tech Service, China Marrow Donor Program, Beijing, China.
31
Department of HLA Laboratory, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.
32
The Key Laboratory of Geriatrics, Beijing Hospital, Beijing Institute of Geriatrics, Ministry of Health, Beijing, China.
33
China Bone Marrow Program, Quality Control Laboratory, Beijing, China.

Abstract

The American Society for Histocompatibility and Immunogenetics HLA common and well-documented (CWD) catalog, CWD 2.0.0 catalog and European Federation for Immunogenetics (EFI) CWD catalog have been published, which are useful for improving the accuracy of HLA genotyping in laboratories. Here, we studied the Chinese HLA CWD catalog. A total of 812 211 unrelated volunteer donors from the China Marrow Donor Program (CMDP) were analyzed. Six hundred seventy-six alleles at the HLA-A, -B, -C, -DRB1, and -DQB1 loci were defined as CWD alleles in the Chinese population, including 159 common and 517 well-documented alleles. The distribution of HLA alleles in the Chinese CWD catalog is different from that in the EFI CWD catalog. Thirty-two percent (215/676) of CWD alleles in the Chinese CWD catalog are shared with those in the EFI CWD catalog. Fifty-six percent (380/676) of alleles in the Chinese CWD catalog are not found in the EFI CWD catalog, while 655 alleles in the EFI CWD catalog are neither common nor well-documented alleles in the Chinese CWD catalog. The Chinese CWD catalog described in this study may help to improve high-resolution histocompatibility testing for CMDP-accredited laboratories in China. However, to accommodate an increasing number of HLA alleles, this Chinese CWD catalog should be regularly updated.

KEYWORDS:

ASHI; Chinese population; EFI; HLA; common and well-documented allele

PMID:
30073798
DOI:
10.1111/tan.13358

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center