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J Cell Physiol. 2018 Aug 2. doi: 10.1002/jcp.27096. [Epub ahead of print]

Evidence of curcumin and curcumin analogue effects in skin diseases: A narrative review.

Author information

1
Chemical Injuries Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
2
Department of Chemistry, Faculty of Science, K.N. Toosi University of Technology, Tehran, Iran.
3
Weill Cornell Medicine Qatar, Doha, Qatar.
4
Sabinsa Corporation, East Windsor, New Jersey.
5
Life Sciences Research Division, Anti-Doping Laboratory Qatar, Doha, Qatar.
6
Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, Kansas City, Missouri.
7
Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
8
Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
9
School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

Abstract

Curcumin, a natural polyphenolic and yellow pigment obtained from the spice turmeric, has strong antioxidative, anti-inflammatory, and antibacterial properties. Due to these properties, curcumin has been used as a remedy for the prevention and treatment of skin aging and disorders such as psoriasis, infection, acne, skin inflammation, and skin cancer. Curcumin has protective effects against skin damage caused by chronic ultraviolet B radiation. One of the challenges in maximizing the therapeutic potential of curcumin is its low bioavailability, limited aqueous solubility, and chemical instability. In this regard, the present review is focused on recent studies concerning the use of curcumin for the treatment of skin diseases, as well as offering new and efficient strategies to optimize its pharmacokinetic profile and increase its bioavailability.

KEYWORDS:

curcumin; dermatology; inflammation; skin; topical use

PMID:
30073647
DOI:
10.1002/jcp.27096

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