Format

Send to

Choose Destination
J Perinatol. 2018 Oct;38(10):1337-1343. doi: 10.1038/s41372-018-0188-6. Epub 2018 Aug 2.

Integrated evaluation of hemodynamics: a novel approach for the assessment and management of preterm infants with compromised systemic circulation.

Author information

1
Section of Neonatology, University of Manitoba, Winnipeg, Manitoba, Canada. yelsayed@exchange.hsc.mb.ca.
2
Section of Neonatology, University of Manitoba, Winnipeg, Manitoba, Canada.
3
Departments of Pediatrics and Physiology, Division of Neonatology, Hospital for Sick Children, Toronto, ON, Canada.

Abstract

OBJECTIVE:

To establish normal reference values for tissue oxygen delivery and consumption in preterm infants and demonstrate the usefulness of the integrated evaluation of hemodynamics (IEH) in preterm infants with compromised systemic circulation (CSC).

METHODS:

This study included 32 stable preterm infants and 6 infants (selected cases) who underwent IEH. IEH is a multimodal approach which integrates clinical parameters: data obtained from near-infrared spectroscopy (NIRS) and targeted neonatal echocardiography (TNE).

RESULTS:

Thirty-two hemodynamically stable preterm infants underwent 57 IEH studies. The mean (10th and 90th percentiles) were 0.23 (0.14 and 0.29) for cerebral fractional oxygen extraction (crFOE), 0.2 (0.13 and 0.24) for renal fractional oxygen extraction (rnFOE), and 0.22 (0.19 and 0.27) for mesenteric fractional oxygen extraction (msFOE). The time to full clinical recovery in all sick infants after the change of management was between 4 and 48 h.

CONCLUSION:

IEH was useful in targeting the management of preterm infants with CSC.

PMID:
30072708
DOI:
10.1038/s41372-018-0188-6

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center