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Clin Med (Lond). 2018 Aug;18(4):282-287. doi: 10.7861/clinmedicine.18-4-282.

Risk of thromboembolism in patients developing critical illness-associated atrial fibrillation.

Author information

1
Derriford Hospital, Plymouth, UK benjamin.clayton@nhs.net.
2
NIHR CLAHRC South West Peninsula (PenCLAHRC), University of Exeter Medical School, University of Exeter, Exeter, UK.
3
Derriford Hospital, Plymouth, UK.
4
Intensive Care, Derriford Hospital, Plymouth, UK.

Abstract

Although common, the long-term significance of -developing atrial fibrillation (AF) during a period of critical illness is unclear. We undertook a retrospective cohort analysis to -assess the rate of thromboembolism (TE) in patients -developing atrial fibrillation de novo during admission to our intensive care unit. In total, 1,955 patients were followed up (-maximum follow-up 1,276 days) for the occurrence of TE, of which 220 (11.3%) had developed AF or atrial flutter during their critical care admission. There were 11 TE events among the patients with new AF (0.053 events per patient-year), compared with 18 in the non-AF group (0.0059 events per patient-year). The unadjusted hazard ratio for TE in patients developing new AF compared with those not developing AF was 8.09 (95% CI 3.08-17.19, p<0.001). In patients admitted to critical care, the development of AF appears to be associated with a significantly increased risk of subsequent thromboembolism.

KEYWORDS:

Atrial fibrillation; critical care; critical illness; intensive care; stroke; thromboembolism

Comment in

PMID:
30072549
PMCID:
PMC6334048
DOI:
10.7861/clinmedicine.18-4-282
[Indexed for MEDLINE]
Free PMC Article

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