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Cancer Sci. 2018 Aug 2. doi: 10.1111/cas.13759. [Epub ahead of print]

The roles of fibroblast growth factor receptor 4 in cancers.

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State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.


Fibroblast growth factor receptors (FGFRs) play significant roles in both embryonic development and in adults. Upon binding with ligands, FGFR signaling is activated and triggers various downstream signal cascades that are implicated in diverse biological processes. Aberrant regulations of FGFR signaling are detected in numerous cancers. Although FGFR4 was discovered later than other FGFRs, the knowledges of the involvement of FGFR4 in cancers significantly increased in recent years. In this review, the recent findings in FGFR4 structure, signaling transduction, physiological function, aberrant regulations and effects in cancers as well as its potential applications as an anti-cancer therapeutic target are summarized. This article is protected by copyright. All rights reserved.


FGFR4; aberrant signaling pathway; cancer; dysregulation; therapeutic targets

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