Format

Send to

Choose Destination
Cancer Sci. 2018 Oct;109(10):3024-3031. doi: 10.1111/cas.13759. Epub 2018 Oct 3.

Role of fibroblast growth factor receptor 4 in cancer.

Author information

1
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

Abstract

Fibroblast growth factor receptors (FGFR) play a significant role in both embryonic development and in adults. Upon binding with ligands, FGFR signaling is activated and triggers various downstream signal cascades that are implicated in diverse biological processes. Aberrant regulations of FGFR signaling are detected in numerous cancers. Although FGFR4 was discovered later than other FGFR, information on the involvement of FGFR4 in cancers has significantly increased in recent years. In this review, the recent findings in FGFR4 structure, signaling transduction, physiological function, aberrant regulations, and effects in cancers as well as its potential applications as an anticancer therapeutic target are summarized.

KEYWORDS:

aberrant signaling pathway; cancer; dysregulation; fibroblast growth factor receptor 4; therapeutic target

PMID:
30070748
PMCID:
PMC6172014
DOI:
10.1111/cas.13759
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center