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Analyst. 2018 Oct 8;143(20):4836-4839. doi: 10.1039/c8an00913a.

In vivo detection of drug-induced apoptosis in tumors using Raman spectroscopy.

Author information

1
Department of Radiology, Brigham & Women's Hospital, Boston, MA 02115, USA. ojonas@bwh.harvard.edu.

Abstract

We describe a label-free approach based on Raman spectroscopy, to study drug-induced apoptosis in vivo. Spectral-shifts at wavenumbers associated with DNA, proteins, lipids, and collagen have been identified on breast and melanoma tumor tissues. These findings may enable a new analytical method for rapid readout of drug-therapy with miniaturized probes.

PMID:
30070266
PMCID:
PMC6175619
[Available on 2019-10-08]
DOI:
10.1039/c8an00913a
[Indexed for MEDLINE]

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