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Am J Med Genet B Neuropsychiatr Genet. 2018 Aug 2. doi: 10.1002/ajmg.b.32639. [Epub ahead of print]

A longitudinal approach to biological psychiatric research: The PsyCourse study.

Author information

1
Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.
2
Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, Goettingen, Germany.
3
Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany.
4
International Max Planck Research School for Translational Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany.
5
Department of Translational Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany.
6
Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany.
7
Department of Psychiatry, Ruhr University Bochum, LWL University Hospital, Bochum, Germany.
8
Department of Psychiatry, University of Münster, Münster, Germany.
9
Department of Psychiatry and Psychotherapy, Bezirkskrankenhaus Augsburg, Augsburg, Germany.
10
Psychiatrieverbund Oldenburger Land gGmbH, Karl-Jaspers-Klinik, Bad Zwischenahn, Germany.
11
Department of Psychiatry, Klinikum Bremen-Ost, Bremen, Germany.
12
German Center for Neurodegenerative Diseases (DZNE), Goettingen, Germany.
13
iBiMED, Medical Sciences Department, University of Aveiro, Aveiro, Portugal.
14
Department of Psychiatry and Psychotherapeutic Medicine, Research Unit for Bipolar Affective Disorder, Medical University of Graz, Graz, Austria.
15
Department of Psychiatry, Dr. Fontheim-Mental Health, Liebenburg, Germany.
16
Discipline of Psychiatry, Royal Adelaide Hospital, Adelaide Medical School, The University of Adelaide, Adelaide, Australia.
17
Department of Psychiatry and Psychotherapy, Agaplesion Diakonieklinikum, Rotenburg, Germany.
18
Karl-Jaspers Clinic, European Medical School Oldenburg-Groningen, Oldenburg, Germany.
19
Clinic for Psychiatry and Psychotherapy, Clinical Center Werra-Meißner, Eschwege, Germany.
20
Asklepios Specialized Hospital, Göttingen, Germany.
21
Department of Psychiatry II, Ulm University, Bezirkskrankenhaus Günzburg, Günzburg, Germany.
22
AMEOS Clinical Center Hildesheim, Hildesheim, Germany.
23
Center for Systems Neuroscience (ZSN), Hannover, Germany.
24
Psychiatric Hospital Lüneburg, Lüneburg, Germany.
25
AMEOS Clinical Center Osnabrück, Osnabrück, Germany.
26
ASKLEPIOS Specialized Hospital Tiefenbrunn, Rosdorf, Germany.
27
Department of Psychiatry, Psychotherapy and Psychosomatics, Clinical Center Wilhelmshaven, Wilhelmshaven, Germany.
28
Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
29
Institute of Human Genetics, University of Bonn School of Medicine & University Hospital Bonn, Bonn, Germany.
30
Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany.
31
Human Genomics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland.
32
Department of Psychiatry (UPK), University of Basel, Basel, Switzerland.

Abstract

In current diagnostic systems, schizophrenia and bipolar disorder are still conceptualized as distinct categorical entities. Recently, both clinical and genomic evidence have challenged this Kraepelinian dichotomy. There are only few longitudinal studies addressing potential overlaps between these conditions. Here, we present design and first results of the PsyCourse study (N = 891 individuals at baseline), an ongoing transdiagnostic study of the affective-to-psychotic continuum that combines longitudinal deep phenotyping and dimensional assessment of psychopathology with an extensive collection of biomaterial. To provide an initial characterization of the PsyCourse study sample, we compare two broad diagnostic groups defined by the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) classification system, that is, predominantly affective (n = 367 individuals) versus predominantly psychotic disorders (n = 524 individuals). Depressive, manic, and psychotic symptoms as well as global functioning over time were contrasted using linear mixed models. Furthermore, we explored the effects of polygenic risk scores for schizophrenia on diagnostic group membership and addressed their effects on nonparticipation in follow-up visits. While phenotypic results confirmed expected differences in current psychotic symptoms and global functioning, both manic and depressive symptoms did not vary between both groups after correction for multiple testing. Polygenic risk scores for schizophrenia significantly explained part of the variability of diagnostic group. The PsyCourse study presents a unique resource to research the complex relationships of psychopathology and biology in severe mental disorders not confined to traditional diagnostic boundaries and is open for collaborations.

KEYWORDS:

RDoC; affective disorder; diagnosis; polygenic risk score; psychosis

PMID:
30070057
DOI:
10.1002/ajmg.b.32639

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