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Clin Rheumatol. 2018 Aug 1. doi: 10.1007/s10067-018-4231-y. [Epub ahead of print]

Gene and miRNA expression in giant cell arteritis-a concise systematic review of significantly modified studies.

Author information

1
Department of Rheumatology, University Medical Centre Ljubljana, Vodnikova cesta 62, 1000, Ljubljana, Slovenia. tadejakuret@gmail.com.
2
Department of Rheumatology, University Medical Centre Ljubljana, Vodnikova cesta 62, 1000, Ljubljana, Slovenia. blaz.burja@gmail.com.
3
Institute of Computational Biotechnology, Graz University of Technology, Petersgasse 14, 8010, Graz, Austria.
4
OMICS Center Graz, BioTechMed Graz, Stiftingtalstraße 24, 8010, Graz, Austria.
5
Department of Rheumatology, Center of Experimental Rheumatology, University Hospital Zurich, Wagistrasse 14, 8952, Schlieren, Switzerland.
6
Department of Rheumatology, University Medical Centre Ljubljana, Vodnikova cesta 62, 1000, Ljubljana, Slovenia.
7
Faculty of Mathematics, Natural Science and Information Technologies, University of Primorska, Glagoljaška ulica 8, 6000, Koper, Slovenia.
8
Department of Rheumatology, University Medical Centre Ljubljana, Vodnikova cesta 62, 1000, Ljubljana, Slovenia. ssodin1@yahoo.com.
9
Faculty of Mathematics, Natural Science and Information Technologies, University of Primorska, Glagoljaška ulica 8, 6000, Koper, Slovenia. ssodin1@yahoo.com.
10
Faculty of Pharmacy, University of Ljubljana, Aškerčeva cesta 7, 1000, Ljubljana, Slovenia.
11
Faculty of Medicine, University of Ljubljana, Korytkova ulica 2, 1000, Ljubljana, Slovenia.

Abstract

Giant cell arteritis (GCA) is a systemic vasculitis in individuals older than 50 years, characterized by headaches, visual disturbances, painful scalp, jaw claudication, impairment of limb arteries, and systemic inflammation, among other symptoms. GCA diagnosis is confirmed by a positive temporal artery biopsy (TAB) or by imaging modalities. A prominent acute phase response with inflammation is the hallmark of the disease, predominantly targeting large- and medium-sized arteries leading to stenosis or occlusion of arterial lumen. To date, there are no reliable tissue markers specific for GCA. Scarce reports have indicated the importance of epigenetics in GCA. The current systematic review reports significantly changed candidate biomarkers in TABs of GCA patients compared to non-GCA patients using qPCR.

KEYWORDS:

Giant cell arteritis; Temporal artery biopsy; Vasculitis; mRNA expression; miRNA

PMID:
30069799
DOI:
10.1007/s10067-018-4231-y

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