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Biomed Res Int. 2018 Jul 5;2018:1837634. doi: 10.1155/2018/1837634. eCollection 2018.

Extra Dose of Vitamin C Based on a Daily Supplementation Shortens the Common Cold: A Meta-Analysis of 9 Randomized Controlled Trials.

Author information

1
Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
2
Department of Neurology, Nankai Hospital, Tianjin Academy of Integrative Medicine, Tianjin 300100, China.
3
Department of Research and Development, Hangzhou DeBuYou Health Technology Co. Ltd., Hangzhou, Zhejiang 310018, China.
4
College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
5
Department of Chemical Engineering, University of Florida, Gainesville, Florida 32611, USA.

Abstract

Aim:

To investigate whether vitamin C is effective in the treatment of the common cold.

Method:

After systematically searching the National Library of Medicine (PubMed), Cochrane Library, Elsevier, China National Knowledge Infrastructure (CNKI), VIP databases, and WANFANG databases, 9 randomized placebo-controlled trials were included in our meta-analysis in RevMan 5.3 software, all of which were in English.

Results:

In the evaluation of vitamin C, administration of extra therapeutic doses at the onset of cold despite routine supplementation was found to help reduce its duration (mean difference (MD) = -0.56, 95% confidence interval (CI) [-1.03, -0.10], and P = 0.02), shorten the time of confinement indoors (MD = -0.41, 95% CI [-0.62, -0.19], and P = 0.0002), and relieve the symptoms associated with it, including chest pain (MD = -0.40, 95% CI [-0.77, -0.03], and P = 0.03), fever (MD = -0.45, 95% CI [-0.78, -0.11], and P = 0.009), and chills (MD = -0.36, 95% CI [-0.65, -0.07], and P = 0.01).

Conclusions:

Extra doses of vitamin C could benefit some patients who contract the common cold despite taking daily vitamin C supplements.

PMID:
30069463
PMCID:
PMC6057395
DOI:
10.1155/2018/1837634
[Indexed for MEDLINE]
Free PMC Article

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