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Bioessays. 2018 Oct;40(10):e1800111. doi: 10.1002/bies.201800111. Epub 2018 Aug 1.

Does Calorie Restriction in Primates Increase Lifespan? Revisiting Studies on Macaques (Macaca mulatta) and Mouse Lemurs (Microcebus murinus).

Author information

1
Centre de Recherches sur la Cognition Animale, Centre de Biologie Intégrative, Université de Toulouse, 31062, Toulouse cedex, France.

Abstract

The effects of calorie restriction have now been studied in two non-human primates, the macaque Macaca mulatta and the mouse lemur Microcebus murinus. The study on lemurs and one of the two studies on macaques have reported a lifespan increase. In this review, I argue that these results are better explained by a lifespan decrease in the control group because of a bad diet and/or overfeeding, rather than by a real lifespan increase in calorie-restricted animals. If these results can be readily translated to humans, it would mean that no beneficial effect of calorie restriction on lifespan can be expected in normal-weight or lean people, but that overweight and/or obese people could benefit to some extent from a decrease in excessive food intake.

KEYWORDS:

calorie restriction; human beings; non-human primates

PMID:
30067295
DOI:
10.1002/bies.201800111

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