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Bioessays. 2018 Oct;40(10):e1800111. doi: 10.1002/bies.201800111. Epub 2018 Aug 1.

Does Calorie Restriction in Primates Increase Lifespan? Revisiting Studies on Macaques (Macaca mulatta) and Mouse Lemurs (Microcebus murinus).

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Centre de Recherches sur la Cognition Animale, Centre de Biologie Intégrative, Université de Toulouse, 31062, Toulouse cedex, France.


The effects of calorie restriction have now been studied in two non-human primates, the macaque Macaca mulatta and the mouse lemur Microcebus murinus. The study on lemurs and one of the two studies on macaques have reported a lifespan increase. In this review, I argue that these results are better explained by a lifespan decrease in the control group because of a bad diet and/or overfeeding, rather than by a real lifespan increase in calorie-restricted animals. If these results can be readily translated to humans, it would mean that no beneficial effect of calorie restriction on lifespan can be expected in normal-weight or lean people, but that overweight and/or obese people could benefit to some extent from a decrease in excessive food intake.


calorie restriction; human beings; non-human primates


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