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Med Sci (Paris). 2018 Jun-Jul;34(6-7):571-579. doi: 10.1051/medsci/20183406017. Epub 2018 Jul 31.

[Caenorhabditis elegans as a model organism for aging: relevance, limitations and future].

[Article in French]

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Univ. Lille, Inserm, CHU Lille, U995 - LIRIC - Lille Inflammation Research International Center, Place de Verdun, F-59000 Lille, France.


Aging is a physiological and complex process associated with increasing age of living organisms. Simple model organisms have brought significant advances in our understanding of the aging process. Caenorhabditis elegans, a nematode originally used to establish the genetic and molecular basis of development, has become one of the leading model organisms for research on aging. This invertebrate has allowed identifying a connection between cellular signaling pathways and longevity. Although C. elegans is not suitable for analysis of the complete process of human aging, it remains a model of choice to analyze specific aging mechanisms and phenotypes.

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