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J Neurophysiol. 2018 Oct 1;120(4):1914-1922. doi: 10.1152/jn.00398.2018. Epub 2018 Aug 1.

The interplay between electrical and chemical synaptogenesis.

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National Centre for Biological Sciences, Tata Institute for Fundamental Research , Bangalore , India.
Manipal Academy of Higher Education, Madhav Nagar, Manipal , India.


Neurons communicate with each other via electrical or chemical synaptic connections. The pattern and strength of connections between neurons are critical for generating appropriate output. What mechanisms govern the formation of electrical and/or chemical synapses between two neurons? Recent studies indicate that common molecular players could regulate the formation of both of these classes of synapses. In addition, electrical and chemical synapses can mutually coregulate each other's formation. Electrical activity, generated spontaneously by the nervous system or initiated from sensory experience, plays an important role in this process, leading to the selection of appropriate connections and the elimination of inappropriate ones. In this review, we discuss recent studies that shed light on the formation and developmental interactions of chemical and electrical synapses.


activity; circuit assembly; connexin; development; dye coupling; electrotonic coupling; gap junctions; innexin

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