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J Neurophysiol. 2018 Nov 1;120(5):2246-2259. doi: 10.1152/jn.00079.2018. Epub 2018 Aug 1.

Cognitive load reduces the effects of optic flow on gait and electrocortical dynamics during treadmill walking.

Malcolm BR1,2, Foxe JJ1,2,3,4,5, Butler JS1,5,6,7, Molholm S1,2,3,4, De Sanctis P1,2,8.

Author information

1
The Sheryl & Daniel R. Tishman Cognitive Neurophysiology Laboratory, Children's Evaluation and Rehabilitation Center, Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York.
2
Program in Cognitive Neuroscience, The Graduate Center of the City University of New York , New York, New York.
3
The Del Monte Institute for Neuroscience, Department of Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, New York.
4
The Dominick P. Purpura Department of Neuroscience, Rose F. Kennedy Intellectual and Developmental Disabilities Research Center, Albert Einstein College of Medicine, Bronx, New York.
5
Trinity College Institute of Neuroscience , Dublin , Ireland.
6
Centre for Bioengineering, Trinity Biomedical Sciences Institute, Trinity College Dublin , Dublin , Ireland.
7
School of Mathematical Sciences, Dublin Institute of Technology , Dublin , Ireland.
8
The Saul R. Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, New York.

Abstract

During navigation of complex environments, the brain must continuously adapt to both external demands, such as fluctuating sensory inputs, and internal demands, such as engagement in a cognitively demanding task. Previous studies have demonstrated changes in behavior and gait with increased sensory and cognitive load, but the underlying cortical mechanisms remain largely unknown. In the present study, in a mobile brain/body imaging (MoBI) approach, 16 young adults walked on a treadmill with high-density EEG while 3-dimensional (3D) motion capture tracked kinematics of the head and feet. Visual load was manipulated with the presentation of optic flow with and without continuous mediolateral perturbations. The effects of cognitive load were assessed by the performance of a go/no-go task on half of the blocks. During increased sensory load, participants walked with shorter and wider strides, which may indicate a more restrained pattern of gait. Interestingly, cognitive task engagement attenuated these effects of sensory load on gait. Using an independent component analysis and dipole-fitting approach, we found that cautious gait was accompanied by neuro-oscillatory modulations localized to frontal (supplementary motor area, anterior cingulate cortex) and parietal (inferior parietal lobule, precuneus) areas. Our results show suppression in alpha/mu (8-12 Hz) and beta (13-30 Hz) rhythms, suggesting enhanced activation of these regions with unreliable sensory inputs. These findings provide insight into the neural correlates of gait adaptation and may be particularly relevant to older adults who are less able to adjust to ongoing cognitive and sensory demands while walking. NEW & NOTEWORTHY The neural underpinnings of gait adaptation in humans are poorly understood. To this end, we recorded high-density EEG combined with three-dimensional body motion tracking as participants walked on a treadmill while exposed to full-field optic flow stimulation. Perturbed visual input led to a more cautious gait pattern with neuro-oscillatory modulations localized to premotor and parietal regions. Our findings show a possible brain-behavior link that might further our understanding of gait and mobility impairments.

KEYWORDS:

EEG; dual-task design; independent component analysis (ICA); mobile brain/body imaging (MoBI); power spectral density

PMID:
30067106
PMCID:
PMC6295527
DOI:
10.1152/jn.00079.2018
[Indexed for MEDLINE]
Free PMC Article

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