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J Food Sci Technol. 2018 Aug;55(8):2824-2832. doi: 10.1007/s13197-018-3219-6. Epub 2018 May 21.

Antioxidant properties and anti-quorum sensing potential of Carum copticum essential oil and phenolics against Chromobacterium violaceum.

Author information

1
1LR11ES41: Génétique, Biodiversité et Valorisation des Bio-Ressources, Institut de Biotechnologie, Université de Monastir, 5000 Monastir, Tunisia.
2
2Laboratoire des Maladies Transmissibles et des Substances Biologiquement Actives, Faculté de Pharmacie, Université de Monastir, Monastir, Tunisia.
3
3Yenepoya Research Centre, Yenepoya University, Mangalore, India.
4
4Laboratoire de Biotechnologie de l'Olivier, Centre de Biotechnologie de Borj Cédria, 901, 2050 Hammam Lif, Tunisia.
5
5Institute of Food Science, National Research Council (ISA-CNR), Via Roma 64, 83100 Avellino, Italy.
6
6Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy.
7
7Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, Salerno Italy.
8
8Department of Biochemistry, Faculty of Science, King Abdul Aziz University, Jeddah, Kingdom of Saudi Arabia.

Abstract

The chemical composition, antimicrobial and antioxidant properties of Carum copticum essential oil and its methanolic extract were investigated. Thirteen compounds were identified representing 99.3% of the total oil composition. Oxygenated monoterpenes (53.0%) dominated the C. copticum essential oil with high contents of thymol (51.7 ± 1.51%), p-cymene (26.9 ± 1.11%), γ-terpinene (16.7 ± 0.76%), and β-pinene (1.6 ± 0.15%). In the methanolic extract, the caffeic, gallic, chlorogenic, coumaric and ferulic acids, flavan-3-ols (catechin), flavone (hyperoside), and the flavonol quercetin were identified. Antimicrobial activity of essential oil and the organic extract was tested by disk diffusion and broth microdilution method. The essential oil was effective against the tested bacteria and yeast strains with the highest activity and the MICs and MBCs values were lower as compared to the methanolic extract. The essential oil showed anti-quorum sensing activity against Chromobacterium violaceum, and the IC50 value for violacein inhibition was 0.23 mg/ml. Both the essential oil and the methanolic extract also showed antioxidant activities. The results obtained highlight the potential use of C. copticum as a possible source of antimicrobial and antioxidant compounds to be used both as food flavor and as a broad spectrum antibiotic.

KEYWORDS:

Anti-quorum sensing; Antimicrobial activity; Antioxidant activity; Carum copticum; Essential oil

PMID:
30065392
PMCID:
PMC6045994
[Available on 2019-08-01]
DOI:
10.1007/s13197-018-3219-6

Conflict of interest statement

Compliance with ethical standardsThe authors declare that they have no conflict of interest.

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