Format

Send to

Choose Destination
Sci Rep. 2018 Jul 31;8(1):11484. doi: 10.1038/s41598-018-29855-z.

The Association between Red Blood Cell Distribution Width and Sarcopenia in U.S. Adults.

Author information

1
Department of Preventive Medicine, Gachon University College of Medicine, Incheon, Republic of Korea.
2
Department of Thoracic and Cardiovascular Surgery, Gachon University Gil Medical Centre, Gachon University College of Medicine, Incheon, Republic of Korea.
3
Department of Thoracic and Cardiovascular Surgery, Gachon University Gil Medical Centre, Gachon University College of Medicine, Incheon, Republic of Korea. dr632@gilhospital.com.
4
Department of Preventive Medicine, Gachon University College of Medicine, Incheon, Republic of Korea. yoonchoi@gachon.ac.kr.
5
Gachon Advanced Institute for Health Sciences and Technology, Gachon University, Incheon, Republic of Korea. yoonchoi@gachon.ac.kr.

Abstract

One pathophysiological sign of sarcopenia is chronic inflammation. Given that levels of red blood cell distribution width (RDW) are increased in chronic inflammation, we evaluated the association between increased RDW and sarcopenia among adults in the general U. S. population and analyzed data from 11,761 participants from the National Health and Nutrition Examination Survey (NHANES) 1999-2006. Sarcopenia was defined as an appendicular skeletal muscle mass (ASM) divided by weight (%) that was less than one standard deviation (SD) below the mean of young adults. The odds ratios (ORs) and confidence intervals (CIs) for sarcopenia were calculated across RDW quartiles after adjusting for confounding factors. Elevated RDW levels were significantly associated with sarcopenia after adjusting for age, sex, race, education, household income, smoking, physical activity, hypertension, diabetes, cardiovascular disease, C-reactive protein, and hemoglobin (OR of highest quartile: 1.72 (95% CI: 1.43, 2.06)). Further, in a model stratified by obesity, an elevated RDW was associated with sarcopenia in the overweight and obese group, but not in the normal weight group. Our study shows that elevated RDW is associated with sarcopenia, and this association is particularly strong in people who are overweight and obese.

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center