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Biochem Soc Trans. 2018 Aug 20;46(4):967-982. doi: 10.1042/BST20170568. Epub 2018 Jul 31.

Emerging mechanisms of dynein transport in the cytoplasm versus the cilium.

Author information

1
Institute of Structural and Molecular Biology, Birkbeck, University of London, Malet Street, London, U.K. a.roberts@mail.cryst.bbk.ac.uk.

Abstract

Two classes of dynein power long-distance cargo transport in different cellular contexts. Cytoplasmic dynein-1 is responsible for the majority of transport toward microtubule minus ends in the cell interior. Dynein-2, also known as intraflagellar transport dynein, moves cargoes along the axoneme of eukaryotic cilia and flagella. Both dyneins operate as large ATP-driven motor complexes, whose dysfunction is associated with a group of human disorders. But how similar are their mechanisms of action and regulation? To examine this question, this review focuses on recent advances in dynein-1 and -2 research, and probes to what extent the emerging principles of dynein-1 transport could apply to or differ from those of the less well-understood dynein-2 mechanoenzyme.

KEYWORDS:

cilia; dynein; intraflagellar transport; kinesin; microtubule

PMID:
30065109
PMCID:
PMC6103457
DOI:
10.1042/BST20170568
[Indexed for MEDLINE]
Free PMC Article

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