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Food Chem. 2018 Dec 1;268:355-361. doi: 10.1016/j.foodchem.2018.06.106. Epub 2018 Jun 21.

New biological activity of the polysaccharide fraction from Cantharellus cibarius and its structural characterization.

Author information

1
Chair and Department of Pharmaceutical Botany, Medical University of Lublin, 1 Chodźki Street, 20-093 Lublin, Poland. Electronic address: natalia.nowacka@umlub.pl.
2
Chair and Department of Pharmaceutical Botany, Medical University of Lublin, 1 Chodźki Street, 20-093 Lublin, Poland. Electronic address: renata.nowak@umlub.pl.
3
Department of Pharmaceutical Microbiology, Medical University of Lublin, 1 Chodźki Street, 20-093 Lublin, Poland. Electronic address: marek.juda@umlub.pl.
4
Department of Pharmaceutical Microbiology, Medical University of Lublin, 1 Chodźki Street, 20-093 Lublin, Poland. Electronic address: anna.malm@umlub.pl.
5
Department of Medical Biology, Institute of Rural Health, 2 Jaczewskiego Street, 20-090 Lublin, Poland.
6
Department of Medical Biology, Institute of Rural Health, 2 Jaczewskiego Street, 20-090 Lublin, Poland. Electronic address: rzeski.wojciech@imw.lublin.pl.
7
Faculty of Chemistry, University of Gdansk, 63 Wita Stwosza Street, 80-308 Gdańsk, Poland. Electronic address: zbigniew.kaczynski@ug.edu.pl.

Abstract

One of the most commonly consumed mushrooms in Europe is Cantharellus cibarius, also known as chanterelles. Therefore, the investigation of the pro-health properties of crude polysaccharides from this species was performed. The obtained results indicate that the polysaccharide fraction from C. cibarius inhibits the activity of both COX-1 and COX-2. Moreover, the prebiotic potential was revealed in relation to Lactobacillus strains. Crude polysaccharides were found to inhibit the proliferation of colon cancer cells with the simultaneous absence of toxicity towards normal cells. The purification and structural characterization of the examined polysaccharide fraction from C. cibarius indicates that it consists of one monosaccharide in the repeating unit →6)-α-D-Manp-(1→. The presented activities indicate for the first time that this edible mushroom possesses interesting chemopreventive potential, especially against colon cancer.

KEYWORDS:

Anti-inflammatory; Anticancer; Chemoprevention; Colon cancer; Edible mushroom; Prebiotic

PMID:
30064769
DOI:
10.1016/j.foodchem.2018.06.106
[Indexed for MEDLINE]

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