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Aging (Albany NY). 2018 Jul 31;10(7):1776-1788. doi: 10.18632/aging.101509.

Human methionine synthase A2756G polymorphism increases susceptibility to prostate cancer.

Author information

1
Department of Urology, Third Affiliated Hospital of Nantong University, Wuxi 214041, China.
2
Department of Orthopedics, the Affiliated Jiangyin Hospital of Southeast University Medical School, Jiangyin 214400, China.
3
Department of Urology, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou 213003, Jiangsu Province, China.
4
Department of Nephrourology, Nagoya City University Graduate School of Medical Sciences, Aichi 4678601, Japan.
#
Contributed equally

Abstract

BACKGROUND/AIMS:

Previous results on the association between MTR gene A2756G polymorphism and PCa risk are inconclusive.

METHODS:

We used odds ratios (ORs) with corresponding 95% confidence intervals (95% CIs) to evaluate the correlation between MTR A2756G polymorphism and risk of PCa in meta-analysis. Serum expression of MTR was detected by ELISA and in-silico tools were utilized to assess this variant.

RESULTS:

Our study included 2,921 PCa patients and 3,095 control subjects. The results indicated that the MTR A2756G polymorphism is linked with an increased risk of PCa using three genetic models (G-allele vs. A-allele: OR = 1.16, 95%CI = 1.04 - 1.30; GA vs. AA: OR = 1.17, 95%CI = 1.02 - 1.33; GG+GA vs. AA: OR = 1.18, 95%CI = 1.04 - 1.34). Stratified analysis produced similar results. A significant association was also indicated in advanced PCa from the meta-analysis. Finally, our experiments showed evidence that serum MTR levels in PCa patients with AA genotypes were statistically higher than in those with GG/GA genotypes.

CONCLUSIONS:

Our present study suggests that the MTR A2756G polymorphism may contribute to the risk of developing PCa, particularly in Asian and hospital-based studies. Moreover, serum MTR might be utilized in diagnosis of PCa.

KEYWORDS:

ELISA; genetic variation; methionine synthase; polymorphism; prostate cancer

PMID:
30064122
PMCID:
PMC6075445
DOI:
10.18632/aging.101509
[Indexed for MEDLINE]
Free PMC Article

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