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Environ Int. 2018 Nov;120:43-53. doi: 10.1016/j.envint.2018.07.023. Epub 2018 Jul 29.

Multiple pesticide analysis in hair samples of pregnant French women: Results from the ELFE national birth cohort.

Author information

1
Univ Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, F-35000 Rennes, France. Electronic address: remi.beranger@univ-rennes1.fr.
2
Human Biomonitoring Research Unit, Department of Population Health, Luxembourg Institute of Health, Esch sur Alzette, Luxembourg.
3
Univ Rennes, Inserm, EHESP, Irset - UMR_S 1085, F-35000 Rennes, France.
4
INSERM, Joint Unit INED-INSERM-EFS, Paris, France.
5
European Food Safety Authority (EFSA), Scientific Committee and Emerging Risks Unit (SCER), Parma, Italy.
6
Univ Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, F-35000 Rennes, France.

Abstract

BACKGROUND:

A growing body of evidence suggests that prenatal exposure to pesticides might impair fetal development. Nonetheless, knowledge about pesticide exposure of pregnant women, especially in Europe, is largely restricted to a limited panel of molecules.

AIM:

To characterize the concentration of 140 pesticides and metabolites in hair strands from women in the ELFE French nationwide birth cohort.

METHODS:

Among cohort members who gave birth in northeastern and southwestern France in 2011, we selected those with a sufficient available mass of hair (n = 311). Bundles of hair 9 cm long were collected at delivery. We screened 111 pesticides and 29 metabolites, including 112 selected a priori based on their reported usage or detection in the French environment. The bundles of hair from 47 women were split into three segments to explore the intraindividual variability of the exposure. Intraclass correlation coefficients (ICCs) were computed for the chemicals with a detection frequency >70%.

RESULTS:

We detected a median of 43 chemicals per woman (IQR 38-47). Overall, 122 chemicals (>20 chemical families) were detected at least once, including 28 chemicals detected in 70-100% of hair samples. The highest median concentrations were observed for permethrin (median: 37.9 pg/mg of hair), p-nitrophenol (13.2 pg/mg), and pentachlorophenol (10.0 pg/mg). The ICCs for the 28 chemicals studied ranged from 0.59 to 0.94.

CONCLUSION:

Pregnant women are exposed to multiple pesticides simultaneously from various chemical families, including chemicals suspected to be reproductive toxicants or endocrine disruptors. The ICCs suggest that the intraindividual variability of pesticide concentrations in hair is lower than its interindividual variability.

KEYWORDS:

Environmental monitoring; Hair; Maternal exposure; Pesticides

PMID:
30064054
DOI:
10.1016/j.envint.2018.07.023
[Indexed for MEDLINE]

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