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Ann Surg Oncol. 2018 Oct;25(11):3396-3403. doi: 10.1245/s10434-018-6677-1. Epub 2018 Jul 30.

Glucose Transporter 1 Gene Variants Predict the Prognosis of Patients with Early-Stage Non-small Cell Lung Cancer.

Do SK1,2, Jeong JY3, Lee SY4,5, Choi JE1,6, Hong MJ1,6, Kang HG1,6, Lee WK7, Seok Y8,9, Lee EB8,9, Shin KM10, Yoo SS8,11, Lee J11, Cha SI11, Kim CH11, Neugent ML12, Goodwin J13,14, Kim JW12, Park JY15,16,17,18,19.

Author information

1
Department of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
2
BK21 Plus KNU Biomedical Convergence Program, Department of Biomedical Science, Kyungpook National University, Daegu, Republic of Korea.
3
Department of Pathology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
4
Lung Cancer Center, Kyungpook National University Chilgok Hospital, Daegu, Republic of Korea. shinyup@knu.ac.kr.
5
Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea. shinyup@knu.ac.kr.
6
Cell and Matrix Research Institute, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
7
Medical Research Collaboration Center in Kyungpook National University Hospital and School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
8
Lung Cancer Center, Kyungpook National University Chilgok Hospital, Daegu, Republic of Korea.
9
Department of Thoracic Surgery, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
10
Department of Radiology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
11
Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
12
Department of Biological Sciences, The University of Texas at Dallas, Richardson, TX, USA.
13
Yale School of Medicine, New Haven, CT, USA.
14
Yale Graduate School of Arts and Sciences, New Haven, CT, USA.
15
Department of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea. jaeyong@knu.ac.kr.
16
BK21 Plus KNU Biomedical Convergence Program, Department of Biomedical Science, Kyungpook National University, Daegu, Republic of Korea. jaeyong@knu.ac.kr.
17
Lung Cancer Center, Kyungpook National University Chilgok Hospital, Daegu, Republic of Korea. jaeyong@knu.ac.kr.
18
Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea. jaeyong@knu.ac.kr.
19
Cell and Matrix Research Institute, School of Medicine, Kyungpook National University, Daegu, Republic of Korea. jaeyong@knu.ac.kr.

Abstract

BACKGROUND:

This study was conducted to investigate whether polymorphisms of glucose transporter 1 (GLUT1) gene are associated with the prognosis of patients with non-small cell lung cancer (NSCLC) after surgical resection.

METHODS:

Five single nucleotide polymorphisms (SNPs) in GLUT1 were investigated in a total of 354 patients with NSCLC who underwent curative surgery. The association of the SNPs with patients' survival was analyzed.

RESULTS:

Among the five SNPs investigated, two SNPs (GLUT1 rs3820589T > A and rs4658G > C) were significantly associated with OS in multivariate analyses. GLUT1 rs3820589T > A was associated with significantly better OS (adjusted hazard ratio [aHR] = 0.57, 95% confidence interval [CI] = 0.34-0.94, P = 0.03, under dominant model), and rs4658G > C was associated with significantly worse OS (aHR = 1.91, 95% CI = 1.09-3.33, P = 0.02, under recessive model). In the stratified analysis by tumor histology, the effect of these SNPs on OS was only significant in squamous cell carcinoma but not in adenocarcinoma. When the two SNPs were combined, OS decreased as the number of bad genotypes increased (Ptrend = 4 × 10-3).

CONCLUSIONS:

This study suggests that genetic variation in GLUT1 may be useful in predicting survival of patients with early stage NSCLC.

PMID:
30062472
DOI:
10.1245/s10434-018-6677-1
[Indexed for MEDLINE]

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